Methylation marks of prenatal exposure to maternal smoking and risk of cancer in adulthood

PA Dugué; AM Hodge; EM Wong; JE Joo; CH Jung; JL Hopper; DR English; GG Giles; RL Milne; MC Southey

Journal article

Methylation marks of prenatal exposure to maternal smoking and risk of cancer in adulthood

PA Dugué, AM Hodge, EM Wong, JE Joo, CH Jung, JL Hopper, DR English, GG Giles, RL Milne, MC Southey

International Journal of Epidemiology | OXFORD UNIV PRESS | Published : 2021

DOI: 10.1093/ije/dyaa210

Abstract

Background: Prenatal exposure to maternal smoking is detrimental to child health but its association with risk of cancer has seldom been investigated. Maternal smoking induces widespread and long-lasting DNA methylation changes, which we study here for association with risk of cancer in adulthood. Methods: Eight prospective case-control studies nested within the Melbourne Collaborative Cohort Study were used to assess associations between maternal-smoking-associated methylation marks in blood and risk of several cancers: breast (n = 406 cases), colorectal (n = 814), gastric (n = 166), kidney (n = 139), lung (n = 327), prostate (n = 847) and urothelial (n = 404) cancer and B-cell lymphoma (n ..

View full abstract

University of Melbourne Researchers

Allison Hodge Author

Eric Joo Author

Chol-Hee Jung Author

Dallas English Author

Related Projects (6)

Epidemiology of chronic disease, health interventions and DNA studies

Methylation of DNA and colorectal cancer

Methylation of DNA involves a change to the chemical composition of DNA. It can affect the function of genes and normal methylation is essen..

A PROSPECTIVE STUDY OF THE INFLUENCE OF HEALTH - RELATED LIFESTYLE FACTORS ON DNA METHYLATION

It is known that DNA methylation can lead to disease. We aim to discover what causes DNA methylation to change. This could open the way for ..

PRECISION PUBLIC HEALTH FOR MAJOR CANCERS - NOVEL APPROACHES TO BUILDING THE GENETIC, EPIGENETIC AND LIFESTYLE KNOWLEDGE BASE FOR ASSESSING RISK AND PROGNOSIS

The Program of research seeks to increase our understanding of cancer risk. We will use our large collections of population and family-based..

METHYLATION AND THE RISK OF UROTHELIAL CELL CANCER

Why don’t we run prevention programs for urinary tract cancers like we do for others? It’s because we don’t know which lifestyle factors, ex..

METHYLATION AS A RISK FACTOR FOR PROSTATE CANCER

DNA methylation is a process that plays a critical role throughout life by altering the expression of genes. We aim to investigate the poten..

Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This work was supported by the Australian National Health and Medical Research Council (NHMRC) grant 1164455. MCCS cohort recruitment was funded by VicHealth and Cancer Council Victoria. The MCCS was further supported by Australian NHMRC grants 209057, 251553 and 504711 and by infrastructure provided by Cancer Council Victoria. The nested case-control methylation studies were supported by the NHMRC grants 1011618, 1026892, 1027505, 1050198, 1043616 and 1074383. M.C.S. is an NHMRC Senior Research Fellow (1061177).